For modern pharmaceutical company, it’s essential that the processing of products is sanitary and safe. Hence, the compounding system NJR designs for clients is sure to meet the GMP requirement and all the production equipment is sterile.
Besides, in order to produce the medicine in a large scale, the formulate system are all controlled by PLC. Under the condition, the processing can be controlled, tested, analyzed in line. Once there is any problem, the system will alarm so that the quality of medicines can be assured.
Case studies
In the pharmaceutical industry, NJR’s formulation system has been widely used, among which there are a lot of successful cases. Here are a few of our favorites, which bring us precious experience and also tell the quality of the product and service of NJR.
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- Pharma Formulation Tanks for Fat Emulsion Intravenous In order to achieve a better emulsification, the reaction vessels are equipped with high shear mixer and high-pressure homogenization vessels.
Since the high temperature caused during the working of high-pressure homogenizers has a bad impact on the fat emulsion, NJR furnishes the piping system with heat exchanger.
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- Pharmaceutical IV Infusion Compounding System Equip the feed valve of the concentrate tank with control valve and install weight sensor module on the supporting leg of vessel to achieve precise control on weight of feedstock.
The dilution tank uses magnetic mixer to control liquid to a constant volume and the degree of homogeneity.
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- Medical Lyophilized Powder Formulation Processing Equipment The processing of medical lyophilized powder mainly considers the composition of feedstock, the degree of homogeneity and constant volume dilution. Besides, as for design the formulation processing system of medical lyophilized powder in practice, one key is to design the volume of tanks according to the product yield to make sure the equipment in normal operation.
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- Sterile Eye drop Compounding Systems with Formulation Vessels and CIP system Control the flow rate of material by metering pump. At the same time, every compounding system equips with one titanium filter, one 0.45μm microporous filter, two 0.22μm microporous filters and necessary pumps.
Every compounding system has separate CIP and SIP systems.
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- Liquid Oral Processing Equipment The key of liquid oral processing is the pore size of filters. The standard on filtration is lower than that of pharmaceutical IV infusion compounding system. Considering the digestion function of human body, the pore size of filters is usually between 3 um to 5 um.
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- Pharmaceutical Stainless Steel Vessels and Tanks For Syrup Production Since the syrup is taken orally, the production of it must consider the feature of human digestion system. However, the concentration of syrup is usually so high that it’s quite viscous. Hence, the filtration efficiency is lower. Usually, according to client’s requirement, the pore size of filter is between 30 um to 80 um.
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- Pharmaceutical Gels Mixing and Agitation Tanks According to the URS, live steam is introduced to jacket on the vessel to heat the vessel, avoid direct heat and make sure the temperature uniformity.
Calculate the mixing amount and control the volume of reactor. Make sure it satisfies the maximum filling factor and minimum mixing amount.
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- Package Biotech Fermenter Solutions
The design pressure of tank body is -0.1～0.3MPa while the working pressure for jacket is 0.3MPa;
On the top of tank body, a hole is used for feed and inoculate and both the feed point and inoculate point can carry out sterilization, which have no impact on the temperature inside the tank.